A data-driven nutrition framework built on high-fat, high-protein diets and emerging peptide research. Designed for those who refuse to accept average.
Mainstream nutrition has been dominated by carbohydrate-centric models for decades. The evidence is shifting. High-fat, high-protein diets are being rediscovered not just for weight management, but for cognitive clarity, hormonal optimisation, and longevity.
PeakOPTI synthesises cutting-edge metabolic research with animal-based nutritional frameworks you can actually implement — whether you're a student juggling deadlines, or someone investing seriously in long-term performance.
Train your body to efficiently burn both fat and glucose. Reduce energy crashes and sustain deep focus for hours.
Dietary fats are precursors to key hormones. Restriction leads to decline. Sufficiency leads to optimisation.
Every recommendation is cross-referenced against peer-reviewed data. We cite our sources — always.
Short-term gains matter less than compounding returns. Our protocol is built for a lifetime of performance.
Three core pillars. Each backed by research. Each built to compound on the others.
The macro hierarchy, animal food ranking, and the evidence against seed oils. Learn how to structure fat, protein, and carbohydrate intake for maximal metabolic output.
→ Explore NutritionFrom BPC-157 to MOTS-c, explore the frontier of research-grade compounds being studied for tissue regeneration, body recomposition, and longevity signalling.
→ Explore PeptidesKetone cognition, mitochondrial density, anabolic environment, sleep architecture. The six biological pathways that explain why this protocol works.
→ Explore ScienceAnimal foods are the most nutrient-dense substances available to the human body — and the only category of food that delivers every essential nutrient in a form the body can fully absorb and utilise. Meat, organs, eggs, and fatty fish provide complete amino acid profiles, fat-soluble vitamins in their active forms, and compounds — creatine, carnosine, taurine, haem iron, EPA, DHA, choline — that are either absent or biologically insignificant in plant sources. This is not a dietary preference. It is a question of biochemistry.
Organ meats — particularly beef liver — are the single most micronutrient-dense food that exists. A 100g serving of liver delivers more retinol, B12, copper, folate, and CoQ10 than any plant food by an order of magnitude. Fatty fish provide EPA and DHA directly in their pre-formed state, critical for brain structure, neurological function, and systemic inflammation control. Whole eggs — four to six daily — deliver phospholipid-bound DHA, choline for neurotransmitter synthesis, and a complete fat-soluble vitamin matrix in a single food. These are the foods that build hormones, sustain lean mass, and fuel cognitive performance. Build every meal around them.
Red meat from ruminant animals — beef, lamb, bison, venison — provides the highest concentrations of leucine for muscle protein synthesis, alongside zinc, creatine, and carnosine that have no plant equivalent. Saturated animal fat from butter, tallow, and ghee is chemically stable, resistant to oxidation, and the primary structural substrate for every cell membrane and steroid hormone in the body. This is the nutritional foundation that humans evolved on — and the one the body still functions best with.
With that foundation established, the case against non-animal foods becomes straightforward. Grains deliver energy at the cost of insulin spikes, gut disruption, and phytic acid that chelates the very minerals they claim to provide. Fruit is a concentrated fructose delivery mechanism — processed directly by the liver, converted to triglycerides in excess, and incapable of signalling satiety. Vegetables, though culturally revered, are frequently counterproductive: oxalates in leafy greens bind calcium and iron, glucosinolates in cruciferous vegetables suppress thyroid function, and the micronutrients they do contain require fat for absorption and are present in far superior concentrations in animal tissue. None of these foods are necessary. They are at best neutral additions to an already complete animal-food protocol — and at worst, active impediments to it.
Fat and protein aren't the enemy — they are the foundation. Here's how we structure intake for maximal output.
Fat is the most energy-dense macronutrient at 9 kcal/g — more than double that of carbohydrates or protein. Contrary to decades of flawed epidemiology, dietary fat does not cause obesity or cardiovascular disease in isolation. The demonisation of saturated fat was built on cherry-picked data and industry-funded misrepresentation. Animal fats are the original human fuel.
Saturated animal fats — butter, ghee, beef tallow, lamb fat, duck fat, lard — are chemically stable, highly resistant to oxidation, and serve as the direct structural backbone of every cell membrane. They are the primary substrate for steroid hormone synthesis including testosterone, cortisol, and DHEA. Omega-3 fats from wild salmon, sardines, mackerel, and herring deliver EPA and DHA directly in their most bioavailable form — DHA is the dominant structural fat in brain grey matter and retinal tissue. Egg yolk fat is uniquely dense in phospholipid-bound DHA, choline, and fat-soluble vitamins A, D, E, and K2. Avoid all industrial seed oils — they are high in oxidised omega-6 and mechanistically linked to systemic inflammation and mitochondrial dysfunction.
Protein is the literal building material of every structural and functional system in the body — enzymes, hormones, antibodies, contractile muscle fibres, and neurotransmitter precursors are all constructed from amino acids. Insufficient intake doesn't just impair performance; it accelerates biological ageing. Only animal-derived protein delivers the complete amino acid profile in the ratios and bioavailability the human body actually requires.
Red meat — beef, lamb, venison, bison — provides the highest leucine concentrations for mTOR-mediated muscle protein synthesis, alongside haem iron, zinc, creatine, carnosine, and taurine. Organ meats, particularly beef liver, are the single most nutrient-dense food on earth: 100g delivers ~27g protein, full B12 RDA, retinol, copper, folate, CoQ10, and choline. Whole eggs have a biological value of ~100 — the highest of any whole food — with the yolk delivering phospholipid-bound DHA and fat-soluble vitamins. Target 4–6 whole eggs daily, organ meats 2–3× weekly, and fatty fish 3–5× weekly as protocol minimums.
Carbohydrates are the only non-essential macronutrient. The human body has no biological requirement for dietary carbohydrates — glucose can be synthesised endogenously via gluconeogenesis from protein and fat substrates. That does not mean carbs are forbidden, but their role is narrow and strictly context-dependent.
If used at all, restrict strictly to the post-training window, where elevated insulin sensitivity partitions glucose toward muscle glycogen rather than adipose tissue. Many fully fat-adapted individuals perform and recover just as well — or better — with zero dietary carbohydrates, relying entirely on gluconeogenesis. Eliminate all processed grains, refined sugars, and ultra-processed carbohydrate products unconditionally — these provide zero nutritional value and actively disrupt metabolic signalling.
Not all animal foods are equivalent. Here's how we rank them by nutritional density, fat quality, and overall protocol impact.
Beef liver, kidney, heart, and brain. The most nutrient-dense foods in existence. Liver alone covers B12, retinol, copper, folate, CoQ10, and choline in a single 100g serving. Consume 2–3× weekly minimum.
Biological value of ~100 — the highest of any whole food. The yolk delivers phospholipid-bound DHA, choline, fat-soluble vitamins A, D, E, and K2, and a complete amino acid matrix. 4–6 whole eggs daily is the PeakOPTI baseline.
Wild salmon, mackerel, sardines, herring, and anchovies. Unrivalled EPA + DHA delivery alongside complete protein. The anti-inflammatory and neurological benefits are immediate and measurable. Target 3–5 servings weekly.
Ribeye, brisket, lamb shoulder, 80/20 minced beef, venison. Prioritise fattier cuts for combined protein and animal fat delivery. Dense in haem iron, zinc, creatine, carnosine, and fully bioavailable B vitamins.
Chicken thighs, duck breast, turkey legs. Prefer dark meat for fat content. Bone broth from carcasses provides glycine, proline, and collagen precursors for connective tissue and gut lining integrity that muscle meat alone cannot supply.
Butter, ghee, beef tallow, duck fat, lard. Every meal cooked exclusively in animal fat. Structurally stable at high temperatures — unlike seed oils which oxidise and form toxic aldehyde byproducts when heated above their smoke point.
Aged cheese, cream, and full-fat Greek yoghurt from grass-fed sources. High in CLA, vitamin K2, and fat-soluble vitamins. Valuable for those without intolerance. Avoid all skimmed or low-fat dairy variants.
Canola, soybean, sunflower, corn, cottonseed, rapeseed. Industrially extracted, loaded with unstable omega-6, and oxidise rapidly during cooking into toxic aldehydes. Mechanistically linked to systemic inflammation, metabolic dysfunction, and mitochondrial damage.
A peptide is a short chain of amino acids found naturally occurring within the human body. A peptide can be used systemically through subcutaneous injections into body fat to signal to your body's natural receptors to perform a task. Peptides can be used for the brain, skin, metabolism, hormones, muscles and many other areas of physiology.
Peptides are often administered through injections because they work systemically — far more effective than a pill, powder or topical product. This is because they provide rapid, total-body treatment that bypasses the limitations of the digestive system and skin barrier. The result is direct bioavailability at the cellular level.
Peptides have been around for a long time but are often frowned upon for not being "FDA approved" — which is largely irrelevant. FDA approval does not correlate with higher or lower health risk. The FDA has documented financial ties and incentives with sponsoring pharmaceutical companies, meaning industry money is deeply entangled with which products receive approval. This is a regulatory capture problem, not a safety endorsement.
Peptides have not been fully trialled and remain unapproved partly because they are far more complex than a simple pill. Only peptides with major commercial upside — like GLP-1 agonists (Ozempic) — receive approval because they can be mass-produced and sold at scale. Many peptides require careful biological synthesis to correctly format molecules and amino acid sequences, making them commercially unattractive to large pharmaceutical companies.
It is expected that many peptides will never receive formal approval, meaning published human trials may never be undertaken. This can make peptides appear "unsafe" by default. However, with correct biological synthesis and sourcing, a peptide can greatly enhance quality of life for individuals who struggle with sleep, libido, skin health, weight loss, insulin sensitivity, and more — problems that may be inherently genetic or simply resistant to diet alone.
Every peptide featured in this index is sourced exclusively through biological synthesis — the only method capable of producing correctly formatted amino acid sequences that match endogenous human peptides. PeakOPTI maintains a minimum 99% purity threshold across all compounds, verified by third-party HPLC testing. We do not source from chemical synthesis operations or unverified suppliers. Quality of synthesis is the single most important variable in peptide safety and efficacy — and it is non-negotiable.
The most researched healing combination in performance science. BPC-157 drives structural repair at the local tissue level — targeting tendons, ligaments, gut mucosa, and nitric oxide-mediated angiogenesis. TB-500 (Thymosin Beta-4) operates systemically, regulating actin polymerisation and accelerating cell migration to injury sites. Together they create a compounding regenerative effect: localised repair amplified by systemic cellular signalling. Animal model data shows unusually rapid musculoskeletal tissue remodelling with this combination.
A naturally occurring plasma tripeptide (glycine-histidine-lysine) bound to copper, abundant in youth and declining sharply with age — from ~200ng/mL at 20 to under 80ng/mL by 60. GHK-Cu has been shown to modulate over 4,000 human genes: upregulating tissue repair and metabolic health pathways while downregulating inflammatory and oncogenic ones. It supports collagen and elastin synthesis, anti-oxidative gene expression, and DNA repair — representing one of the few peptides with documented systemic anti-ageing effects at the gene regulation level.
CJC-1295 extends endogenous GH pulse half-life through DAC technology, binding albumin to sustain active stimulation for days rather than minutes. Ipamorelin is a selective GHRP that mimics ghrelin at the pituitary without the cortisol or prolactin elevation seen in older GHRPs. Combined, they act on two distinct receptor pathways simultaneously — producing synergistic GH release that mirrors youthful pulsatile physiology. Research applications include lean mass preservation, accelerated fat metabolism, improved sleep architecture, and enhanced recovery.
A first-in-class GLP-1 / GIP / glucagon triple agonist. Phase II data (2023) showed up to 24% body weight reduction over 48 weeks. GLP-1 suppresses appetite; GIP improves nutrient partitioning; glucagon elevates energy expenditure and drives hepatic fat clearance. For body recomposition — fat loss with muscle retention — a conservative low-dose protocol is favoured: 0.5mg weekly (weeks 1–4) for tolerance establishment, escalating to 1–2mg weekly (weeks 5–12) for active recomposition. Pair with 2.2g+ protein per kg bodyweight and resistance training 3–5× weekly to protect lean mass via mTOR signalling.
One of the most extraordinary recent discoveries in peptide science — encoded not by the nuclear genome but by the mitochondrial genome itself. First identified at USC in 2015, MOTS-c is secreted by mitochondria under metabolic stress and functions as a retrograde hormonal signal, travelling to the nucleus to regulate gene expression and systemic metabolism. It activates AMPK — the master cellular energy sensor — and upregulates GLUT4-independent glucose uptake in skeletal muscle, improving insulin sensitivity without insulin involvement. In animal studies, MOTS-c has reversed diet-induced obesity and age-related metabolic decline. Circulating levels decline significantly with age. Combined with an animal-fat-dominant diet, MOTS-c may enhance mitochondrial adaptation to fat oxidation and accelerate the transition to full metabolic flexibility — signalling from the cell's energy centre outward to systemic tissue and gene networks.
High-fat, high-protein nutritional frameworks may create a particularly conducive environment for peptide research protocols. Dietary fat provides the lipid substrate necessary for cell membrane fluidity — which affects receptor sensitivity. Protein sufficiency ensures amino acid availability for endogenous peptide synthesis. The emerging hypothesis: that optimal macronutrient intake may potentiate the effects observed in peptide studies, while also reducing the anabolic resistance seen in suboptimal nutritional states. This is an active and exciting area of investigation at the intersection of nutritional biochemistry and peptide pharmacology.
Six biological pathways that explain the protocol at a molecular level — from mitochondrial function to hormonal architecture.
Beta-hydroxybutyrate is a preferred substrate for the brain, crossing the blood-brain barrier more efficiently than glucose in certain states. Sustained fat oxidation supports neurological energy without glycaemic volatility.
High-fat diets combined with strategic training protocols are associated with improvements in mitochondrial biogenesis via PGC-1α upregulation — the master regulator of energy metabolism.
Adequate dietary cholesterol and saturated fat intake supports testosterone and other anabolic hormone production. Chronic fat restriction is associated with measurable declines in reproductive hormone profiles.
Protein and fat-dominant pre-sleep nutrition has been associated with improved slow-wave sleep duration and GH pulse amplitude — both critical for physical and cognitive restoration.
EPA and DHA omega-3 fatty acids from fatty fish and egg yolks modulate the NF-κB inflammatory pathway and competitively displace pro-inflammatory omega-6 from cell membranes. Animal-derived omega-3s are immediately bioavailable — unlike ALA from plant sources, which converts to EPA/DHA at less than 5% efficiency in humans.
Animal protein preserves lean mass during caloric restriction through elevated thermic effect (~30% of calories burned in digestion), superior leucine content for mTOR activation, and creatine and carnosine — compounds exclusive to animal tissue that directly enhance intramuscular energy buffering and muscular endurance.
Complete dosing, timing, dietary frameworks, and weekly timelines for all four goal-specific protocols. Select your primary goal below.
Two compounds working across complementary pathways: CJC-1295 and Ipamorelin drive sustained, physiological GH release for lean mass accrual, fat mobilisation, and deep recovery sleep. BPC-157 handles the connective tissue demand of hard training — accelerating tendon and ligament repair so that recovery never limits progress.
The foundational GH stack. CJC-1295 extends and sustains elevated GH levels between sessions, while Ipamorelin produces clean, selective GH pulses at the pituitary — with no cortisol or prolactin elevation. Together they improve lean mass, accelerate fat loss, deepen sleep quality, and speed recovery. Dosed pre-sleep to align with the body's natural nocturnal GH pulse for maximum effect.
High training volume accumulates damage in tendons, ligaments, and muscle tissue. BPC-157 accelerates repair and enhances blood vessel growth to the site of injury, while TB-500 supports rapid cell migration and tissue remodelling. Together they reduce recovery time between sessions and protect the connective tissue that heavy compound lifts place under constant stress.
The majority of GH secretion occurs in the first 90 minutes of sleep. Pre-sleep dosing of CJC-1295 and Ipamorelin amplifies this natural pulse. The peptide stack multiplies the adaptive response to training — but only if the training stimulus is sufficient and sleep is protected. Both are non-negotiable on this protocol.
Protein targets are set to hit leucine thresholds at every meal and drive sustained muscle protein synthesis. Peri-training carbohydrates replenish glycogen and work with the GH-driven anabolic signalling this stack creates. Animal fat provides the hormonal substrate for testosterone and GH. Outside the training window, the default is animal protein and fat.
Foundation phase. Begin BPC-157 daily. Start CJC-1295 and Ipamorelin to establish the GH base. Build training baseline and caloric surplus before ramping intensity.
Growth phase I. Ramp training intensity. GH levels are now consistently elevated — expect noticeable body composition changes and strength gains from week 5 onward.
Consolidation phase. CJC-1295, Ipamorelin, and BPC-157 continue. Maintain training intensity and caloric surplus. Focus on progressive overload and sleep quality.
Peak phase. GH axis is fully optimised — this is typically the most productive window of the cycle. Begin planning the 4-week off-cycle to follow.
Three compounds targeting fat loss from different angles simultaneously: Retatrutide drives powerful appetite suppression and energy expenditure through triple receptor activation. Tesamorelin specifically eliminates stubborn visceral fat by restoring the GH axis. MOTS-c optimises how the body uses and burns fat at the mitochondrial level. Combined with a low-carbohydrate animal food base and resistance training, this stack produces aggressive fat loss while preserving lean mass.
The most potent fat loss peptide available. Retatrutide activates three receptors simultaneously — GLP-1, GIP, and glucagon — producing a powerful and comprehensive metabolic effect. It significantly reduces appetite, slows gastric emptying to extend satiety, elevates energy expenditure, and directly drives fat oxidation. Start low and escalate gradually to build tolerance.
A GHRH analogue that stimulates pulsatile GH release from the pituitary, specifically targeting visceral adipose tissue — the deep abdominal fat surrounding organs that drives inflammation, insulin resistance, and metabolic dysfunction. Where Retatrutide reduces overall body fat, Tesamorelin zeros in on the hardest-to-shift visceral fat and simultaneously supports lean muscle preservation during a caloric deficit.
A mitochondria-derived peptide that activates AMPK — the master metabolic switch. MOTS-c enhances how efficiently muscle tissue burns fat for energy, improves insulin sensitivity, and reverses the metabolic decline that makes sustained fat loss harder with age. It effectively mimics the cellular metabolic effects of exercise, making it especially valuable during a deficit when training capacity is constrained by reduced caloric intake.
Aggressive caloric restriction creates a catabolic environment. BPC-157 supports tissue integrity during the deficit — protecting tendons and connective tissue under the mechanical stress of training when recovery resources are reduced. Its anti-inflammatory and tissue-repair properties keep the body structurally sound through a long cut.
Retatrutide and Tesamorelin both operate most effectively when insulin is suppressed. A low-carbohydrate animal food base keeps insulin low, forcing the body into a fat-oxidising state. MOTS-c amplifies this at the cellular level. Protein targets are non-negotiable — leucine thresholds at every meal preserve the lean mass this stack is designed to protect.
Foundation phase. Begin Retatrutide at 0.5mg weekly. Start Tesamorelin 2mg daily and MOTS-c 3× weekly. Implement low-carbohydrate animal food protocol. Begin BPC-157 daily.
Ramp phase. Retatrutide to 1mg weekly. Appetite suppression becomes significant. Fat oxidation increases as low-carb adaptation completes. Maintain protein targets absolutely.
Peak fat loss phase. Retatrutide to 1.5–2mg based on tolerance. Track body composition weekly. Keep training volume moderate — do not overtrain in a deficit.
Consolidation phase. Transition toward maintenance calories. Reintroduce carbohydrates around training only. Taper Retatrutide in final 2 weeks. Maintain MOTS-c and BPC-157 long-term.
Four compounds targeting distinct cognitive pathways. Semax drives BDNF expression and enhances dopamine, serotonin, and acetylcholine signalling for sharpened focus and working memory. Selank eliminates cognitive interference from stress and anxiety — without sedation. Sermorelin and Ipamorelin amplify deep sleep for memory consolidation and glymphatic brain clearance. MOTS-c fuels the process by optimising neuronal mitochondrial energy.
A synthetic analogue of ACTH that upregulates BDNF — the primary driver of neuroplasticity and new synaptic formation. Semax enhances dopaminergic, serotonergic, and cholinergic signalling to sharpen focus, improve working memory, and accelerate processing speed. Unlike stimulants, it builds receptor sensitivity rather than depleting neurotransmitters. Administered as a nasal spray.
A synthetic analogue of tuftsin. Selank modulates GABA-A activity and enkephalin levels to produce anxiolytic, anti-stress effects without sedation or dependence. It also independently upregulates BDNF, adding to Semax's neuroplasticity signal. The pairing is deliberate: Semax drives cognitive output, Selank removes the stress interference that degrades it.
The brain consolidates memory and clears metabolic waste during deep slow-wave sleep via the glymphatic system. Sermorelin and Ipamorelin amplify the nocturnal GH pulse that drives this process — deepening sleep architecture, extending slow-wave phases, and enhancing the overnight neural maintenance that determines next-day cognitive capacity.
Cognitive performance is ultimately constrained by neuronal energy availability. MOTS-c activates AMPK in brain tissue, optimising mitochondrial efficiency and ATP production in neurons. This directly reduces brain fog, supports sustained mental output over long working sessions, and enhances the metabolic resilience that keeps cognition sharp under stress.
The brain runs most efficiently on ketones when GH signalling and BDNF are elevated. A ketogenic animal food base — heavy in fatty cuts, egg yolks, fatty fish, and organ meats — provides the fat-derived fuel the brain prefers, the DHA and choline required for synaptic membrane integrity, and the cholesterol substrate for neurosteroid synthesis. Zero seed oils, zero refined carbohydrates.
Metabolic foundation. Begin ketogenic dietary protocol and Sermorelin + Ipamorelin pre-sleep only. Allow sleep quality and hormonal baseline to establish before adding cognitive peptides.
Cognitive stack introduction. Add Semax 300mcg intranasal AM. Add Selank 250mcg AM or midday. Add MOTS-c 3× weekly. Full stack running. Expect sharpened focus and improved clarity within 1–2 weeks.
Optimisation phase. Semax can increase to 600mcg from week 5. Dial Selank timing to AM for clarity or midday for afternoon sharpness. Track sleep depth and cognitive output weekly.
Long-term protocol. Semax and Selank continuous. Sermorelin + Ipamorelin 8 weeks on, 2 weeks off. MOTS-c year-round at 3× weekly. Reassess every 12 weeks.
Four compounds addressing skin quality, tissue repair, and cellular ageing at every level. GHK-Cu drives collagen synthesis and resets the gene expression of aged skin cells. KPV suppresses the inflammation that degrades collagen and impairs healing. BPC-157 and TB-500 rebuild connective tissue and stimulate the blood vessel growth the dermis needs to repair. Epithalon targets ageing at the cellular root — restoring telomere integrity and melatonin production simultaneously.
A naturally occurring copper-binding tripeptide that declines significantly with age. GHK-Cu stimulates collagen I and III synthesis, improves elastin production, increases skin density and thickness, reduces fine lines, and reverses hyperpigmentation. It influences the expression of thousands of genes linked to tissue repair, inflammation, and cellular regeneration — effectively resetting the gene expression profile of aged skin cells toward more youthful states.
A tripeptide derived from alpha-melanocyte-stimulating hormone that delivers potent anti-inflammatory effects. KPV suppresses NF-κB — the master regulator of systemic inflammation — and reduces TNF-α and IL-6, the inflammatory cytokines most responsible for the chronic low-grade inflammation that degrades collagen, impairs wound repair, and accelerates visible skin ageing. By clearing the inflammatory environment, KPV enhances GHK-Cu's regenerative signal.
For deep structural regeneration beneath the surface. BPC-157 stimulates angiogenesis — new blood vessel formation — which directly supplies the dermal matrix with the nutrients and oxygen needed for collagen synthesis and wound repair. TB-500 promotes cell migration and tissue remodelling, accelerating healing quality across all tissue types. Together they are the connective tissue backbone of this protocol, supporting scar remodelling and deep dermal matrix repair.
A tetrapeptide derived from pineal gland extracts that activates telomerase — the enzyme responsible for maintaining and rebuilding telomeres, the protective caps on chromosomes that shorten with every cell division. As telomeres shorten, cells age and lose their regenerative capacity. Epithalon restores telomerase activity, slowing cellular ageing at its source. It also restores pineal melatonin production — improving deep sleep and circadian rhythm regulation as a compounding benefit.
The diet underpinning this protocol directly supplies the raw materials for collagen synthesis and skin repair. Organ meats deliver retinol, copper, and zinc — cofactors essential for GHK-Cu's collagen-stimulating mechanism. Bone broth provides glycine and hydroxyproline, the amino acids collagen is built from. Fatty fish supplies EPA and DHA for membrane integrity. Seed oils are strictly excluded — they drive the oxidative stress and inflammation that every compound in this stack is working to reverse.
Foundation phase. Begin GHK-Cu injectable 3–5× weekly and topical 2× daily. Start KPV daily. Begin BPC-157 daily and TB-500 loading. Implement full dietary protocol.
First Epithalon cycle. Run Epithalon 10mg daily for 10–14 days. Continue GHK-Cu, KPV, BPC-157, and TB-500 maintenance. The combination of GHK-Cu's regenerative signalling and Epithalon's telomere support creates the most potent anti-ageing window in the protocol.
Active regeneration phase. Epithalon off-cycle. TB-500 continues at maintenance. GHK-Cu, KPV, and BPC-157 ongoing. Skin density and texture improvements typically visible from week 6–8.
Long-term protocol. GHK-Cu and KPV indefinitely. BPC-157 year-round. Epithalon 2–3 burst cycles per year at 3-month and 6-month marks.
// All protocols are for educational and research purposes only. Dosing information reflects ranges cited in existing literature and does not constitute medical advice. Consult a qualified physician before initiating any peptide protocol.
Three compounds targeting the cellular damage caused by alcohol, smoking, recreational drugs, and chronic dietary abuse. Glutathione tackles oxidative overload and liver toxicity at the molecular level. MOTS-c restores the mitochondrial machinery that chronic substance use breaks down. NAD+ replenishes the coenzyme depleted by heavy alcohol and drug metabolism — the same depletion responsible for the fatigue, brain fog, and impaired recovery that follow sustained lifestyle damage.
Glutathione is the body's primary cellular antioxidant and detoxification agent. It neutralises reactive oxygen species (ROS) generated by alcohol, drug, and cigarette metabolism — the same ROS responsible for liver inflammation, DNA damage, and accelerated cellular ageing. Through glutathione S-transferase activity, it conjugates and clears toxic metabolites the liver cannot otherwise process efficiently. Chronic substance use depletes endogenous glutathione reserves; exogenous replenishment directly restores the body's capacity for cellular self-repair.
A mitochondria-derived peptide that activates the AMPK pathway — the master regulator of cellular energy balance. Chronic alcohol and drug use damages mitochondrial function directly, impairing the cell's ability to generate ATP and regulate metabolic signalling. MOTS-c restores mitochondrial efficiency, improves insulin sensitivity, and counteracts the chronic metabolic dysfunction that follows sustained lifestyle damage. It works synergistically with NAD+ to re-establish the cellular energy infrastructure that substance abuse depletes.
Nicotinamide Adenine Dinucleotide is a coenzyme central to oxidation-reduction reactions and mitochondrial energy production. Alcohol metabolism consumes NAD+ at an accelerated rate, converting it to NADH and disrupting redox balance across every metabolic pathway that depends on it — fatty acid oxidation, gluconeogenesis, and the TCA cycle. Drug and nicotine use further deplete reserves through inflammatory and oxidative mechanisms. Replenishing NAD+ restores sirtuins involved in DNA repair, reverses the energetic deficit at cellular level, and directly addresses the fatigue and cognitive impairment of detox.
Acute detox phase. NAD+ daily loading (500mg). Glutathione 3× per week. MOTS-c every other day. Focus on clearing the acute toxic load — expect improved energy and reduced brain fog by end of week 2.
Cellular repair phase. NAD+ 3× per week. Glutathione 2× per week. MOTS-c 3× per week. Mitochondrial function improving — sleep quality, mood, and metabolic markers typically stabilise during this window.
Revitalisation phase. All three compounds at maintenance dosing. The compounding effect of restored glutathione, NAD+, and MOTS-c produces measurable improvements in body composition, cognitive output, and systemic inflammation markers.
Maintenance protocol. Weekly NAD+ and Glutathione. MOTS-c cycling 8 weeks on / 4 weeks off. Recommended for anyone with ongoing lifestyle exposures.
// All protocols are for educational and research purposes only. Dosing information reflects ranges cited in existing literature and does not constitute medical advice. Consult a qualified physician before initiating any peptide protocol.